Programma dag 2
- 10:30-11:15
- Zaal 1
Keynote: The effect of higher sensitivity on the evidential value of traces in forensic chemistry
- Marcel de Puit Sr. Scientist / assoc. prof., NFI / TUDelft
The production, distribution, sale and use of illicit materials is big problem in society, with considerable effect on public health and safety. There is great demand for better and more R&D for the analysis of illicit materials and the use thereof in the criminal justice system. In this presentation we will discuss the effect of an increased sensitivity in some analytical methods on the evidential value in forensic chemistry. We will show the results of the studies we have carried out over the past few years on the analysis of illicit materials in a forensic setting.
- 11:30-11:55
- Zaal 1
Insights in block length distributions of thermoplastic polyurethans and polyesters
- Harry Philipsen Senior Expert Structure and Analytics, DSM Engineering Materials
The average length of the constituting blocks in a block copolymer can be determined by spectroscopy, especially NMR. However, no information is obtained on the block length distribution. This would be important info though as especially the longer blocks fraction is thought to be responsible for e.g., crystallinity.
Recently, we investigated whether further insights in differences in block length distributions can be obtained by (off-line) coupled chromatography followed by NMR. By decoupling molar mass and chemical composition effects in the interactive chromatography step access to block length distributional information can be obtained as was shown by NMR experiments of 2D fractions. From the accurate description of residual molar mass effects and via non-parametric deconvolution semi-quantitative differences in block length distributions between individual samples could be determined.
- 11:55-12:20
- Zaal 1
in-depth characterization of complex co-polymers
- Rick van den Hurk PhD Candidate, University of Amsterdam
Co-polymers are ubiquitous in modern society as they provide tunability for specific desired chemical and physical properties. To create higher-quality products, it is important to understand the underlying chemical structure that results in the desired physical properties of the final product. The block-length distribution of a copolymer is an important parameter that remains challenging to characterize. To date, most methods aimed at block copolymers characterize average block lengths but cannot comment on its distribution. In this study, we aim to characterize complex co-polymers by investigating the block-length distribution.
- 12:20-12:45
- Zaal 1
Hyphenation of Liquid Chromatography with Pyrolysis based Detection Methods for Copolymer Characterization.
- Wouter Knol PhD student, Universiteit van Amsterdam
The characterization of chemical heterogeneities over the molar mass distribution of copolymers is challenging but crucial to the development of novel materials. A variety of methods have been developed to study these heterogeneities, mostly relying on the coupling of detectors which offer chemical information to molar mass separations by size-exclusion chromatography (SEC). Pyrolysis-gas chromatography (Py-GC), in theory, features excellent sensitivity and resolution, but has seen little application as a chemical detector in SEC. In this lecture, we cover the development of an SEC-Py-GC-MS and SEC-Py-FID/MS analysis methods for copolymers, yielding sequence and chemical composition information over the molar mass distribution.
- 13:45-14:30
- Zaal 1
The future of plastics. High potential polyesters from biomass and CO2
- Gert-Jan Gruter University of Amsterdam
• Instead of producing renewable versions of molecules that we use today (drop-in) such as bio-based ethylene, propylene and para-xylene (for PET monomer terephthalic acid), we will make use of the structure already present in carbohydrates (and CO2) when developing new monomers. These oxygenates will also be the lower cost products from renewable feedstock. In addition, polycondensates (such as polyesters) are designed for (closed-loop) recycling as these polymers can always be converted back to the monomers (which is not possible for the polyolefins such as PE, PP and PS).
• New materials with unique properties, based on sugar and CO2 feedstock such as FDCA (furan dicarboxylic acid), isosorbide, oxalic acid, glycolic acid and lactic acid will be discussed as examples.
- 15:10-15:35
- Zaal 1
SAC DSP
Corbion is a global company originating from the CSM (Centrale Suiker Maatschappij) which is specialized in the production of lactic acid and the derivatives thereof. An overview of Corbion’s broad polymer portfolio, including poly lactic acid (PLA) and other biodegradable copolymers will be given. A current research topic in the field of polymer analysis at Corbion will be highlighted and discussed.
- 15:35-16:00
- Zaal 1
Engineering of cutainases to enable surface hydrolysis and characterization of polyester copolymer
- Eman Abdelraheem Postdoc, University of Amsterdam
Copolymers have varying features which determine the physical and other intrinsic properties of the polymer, such as monomer sequence and end-groups. The Mwt of synthetic copolymers is a major obstacle to their characterization and current analytical technologies can only give limited information on how chemical-composition distributions within a macromolecular structure correlate with the final properties of the material. Therefore, an in-depth analysis of the polymer microstructure is needed.
Herein, we discuss the development of degrading enzymes as analytical tools for the characterization of copolymers. The depolymerization reactions were studied using model homo- and co-polyester polymers. The process was analyzed using LC, LC-MS, SEC-MS to get a deeper understanding of the chemical composition distribution of our co-polyester polymers.
- 10:30-11:15
- Zaal 1
Keynote: The effect of higher sensitivity on the evidential value of traces in forensic chemistry
- Marcel de Puit Sr. Scientist / assoc. prof., NFI / TUDelft
The production, distribution, sale and use of illicit materials is big problem in society, with considerable effect on public health and safety. There is great demand for better and more R&D for the analysis of illicit materials and the use thereof in the criminal justice system. In this presentation we will discuss the effect of an increased sensitivity in some analytical methods on the evidential value in forensic chemistry. We will show the results of the studies we have carried out over the past few years on the analysis of illicit materials in a forensic setting.
- 11:30-11:55
- Zaal 2
- Food Technology
Hoe de software revolutie de agri-food sector verandert en kansen creëert
- Victor Klaren Co-founder en Chief Visionary Officer, Thinkwise
Het belang van software is niet te onderschatten - het kan je bedrijf maken of breken. Maar is de software-industrie wel zo volwassen als we denken? Maatwerk of standaardpakketten met randapplicaties lijken misschien de voor de hand liggende oplossing, maar veroorzaken in werkelijkheid veel problemen. Ontdek in deze presentatie hoe toonaangevende Food bedrijven, zoals Aartsen en Koninklijke Vezet, het Thinkwise Platform inzetten om processen te stroomlijnen en hun concurrentiepositie te versterken met software die nooit meer verouderd. Bovendien stelt het platform IT en business in staat om hand in hand te gaan voor snelle groei door 10x sneller te kunnen ontwikkelen. Ben jij klaar om de markt te veroveren met revolutionaire software?
- 11:55-12:20
- Zaal 2
- Food Technology
Hoe kan digitalisering van laboratorium, pilot-scale en in-proces metingen de duurzaamheid van bedrijfsprocessen verhogen?
- Anita van Rooijen Product manager vloeistof- en gasanalyse, Endress+Hauser
Denk aan productie van voedsel en duurzaamheid; het ver- en gebruik van energie en water…. Wat kan vloeistofanalyse van Endress+Hauser hierbij betekenen?
Punten die ter sprake komen;
• Verminder het risico en de kosten van handmatige bemonstering
• Creëer veilige elektronische records
• Spoor afwijkingen direct op
• Beperk opschalingskosten
• Bewaak uw procesmetingen online
- 12:20-12:45
- Zaal 2
- Food Technology
Fruit- en groenteverwerking in microgolfinstallaties
- Kendra Rademaker Projectcoordinator, MEAM NL
MEAM presenteert de toepassing van industriële schaal magnetron-verwerkingsmogelijkheden van groenten en fruit. Applicaties om kant-en-klare maaltijden microbiologisch veilig maken en het ontdooien van vlees zijn bekend terrein voor MEAM. In deze lezing zal gefocust worden op de energiebesparingen en procestemperaturen bij het drogen van fruit en groente. Door producten op lage temperaturen te drogen kunnen waardevolle bestanddelen in het fruit behouden en door goede procescontrole de hoeveelheid misproductie vermeden worden. Om de mogelijkheden van geschiktheid verder uit te bouwen zal MEAM de eerste cases voorstellen die door Flander’s Food gekozen zijn waar dit jaar een machine geleverd is.
- 13:45-14:30
- Zaal 1
The future of plastics. High potential polyesters from biomass and CO2
- Gert-Jan Gruter University of Amsterdam
• Instead of producing renewable versions of molecules that we use today (drop-in) such as bio-based ethylene, propylene and para-xylene (for PET monomer terephthalic acid), we will make use of the structure already present in carbohydrates (and CO2) when developing new monomers. These oxygenates will also be the lower cost products from renewable feedstock. In addition, polycondensates (such as polyesters) are designed for (closed-loop) recycling as these polymers can always be converted back to the monomers (which is not possible for the polyolefins such as PE, PP and PS).
• New materials with unique properties, based on sugar and CO2 feedstock such as FDCA (furan dicarboxylic acid), isosorbide, oxalic acid, glycolic acid and lactic acid will be discussed as examples.
- 14:45-15:10
- Zaal 2
Capillary electrophoresis in process analytical technology - Monitoring of biopharmaceutical cultivation processes
- Debbie van der Burg PhD candidate, Kantisto / KTH Royal Institute of Technology / TU Braunschweig
To improve biopharmaceutical upstream process monitoring, an analytical control and sensing platform is being developed for continuous monitoring and automated feedback control of the upstream process. Part of this automated, integrated platform consist of (microchip) capillary electrophoresis methods. This presentation will show the results of capillary electrophoresis methods development for mono- and disaccharides, vitamins, and monoclonal antibody monitoring, and the transfer of one of the methods to microchip electrophoresis.
- 15:10-15:35
- Zaal 2
Probing the effects of cortisol and specific receptor involvement in zebrafish larvae using a CE-MS metabolomics workflow
- Marlien Admiraal-van Mever PhD student, Leiden University
Zebrafish (Danio rerio) larvae can fill the gap between cultured cells and mammalian animal models, because they can be obtained in large numbers, are small in size and can easily be manipulated genetically. Given that zebrafish larvae are intrinsically biomass-limited samples, we have developed a capillary electrophoresis-mass spectrometry (CE-MS) workflow for the profiling of (endogenous) metabolites in extracts from individual zebrafish larvae and pools of small numbers of larvae. The CE-MS workflow was used to study the role of the mineralocorticoid receptor in mediating the effects of cortisol in wild-type (WT) and ubiquitous MR-knockout (MRKO) zebrafish larvae model systems.
- 15:35-16:00
- Zaal 2
Multiplexed effector function assessment of antibody glycoforms using ACE-MS
- Christoph Gstoettner Post-Doc, Leiden University Medical Center
Monoclonal antibodies (mAbs) consist of variable domain, interacting with the antigen, and a constant domain, necessary for an immune response via Fcγ receptors, as well as for mAb half-life by interaction with the neonatal Fc receptor (FcRn). Therefore, it is important to study the affinity of mAbs and their proteoforms with these receptors. Common approaches, such as SPR, provide an overall affinity response for all different mAb proteoforms rather than in a proteoform specific manner. In this presentation, we want to show an innovative approach based on sheathless CE-MS to study relative affinities of different mAb proteoforms with the FcRn and FcyRIIa receptor. To determine the separation was performed using ammonium acetate pH 6 or 6.8 for FcRn or FcyRIIa, respectively. We will show that we are able to determine the affinity of mAb proteoforms as a consequence of their different mobility shifts, using different amounts of FcR in the background electrolyte. Hyphenation to MS allowed us to detect the mAb alone as well as in complex with one or two FcRs.
- 10:30-11:15
- Zaal 1
Keynote: The effect of higher sensitivity on the evidential value of traces in forensic chemistry
- Marcel de Puit Sr. Scientist / assoc. prof., NFI / TUDelft
The production, distribution, sale and use of illicit materials is big problem in society, with considerable effect on public health and safety. There is great demand for better and more R&D for the analysis of illicit materials and the use thereof in the criminal justice system. In this presentation we will discuss the effect of an increased sensitivity in some analytical methods on the evidential value in forensic chemistry. We will show the results of the studies we have carried out over the past few years on the analysis of illicit materials in a forensic setting.
- 12:20-12:45
- Zaal 3
Operando time-gated Raman spectroscopy for heterogeneous catalysis
- Robin Vogel PhD candidate, Utrecht University, Inorganic Chemistry and Catalysis
Operando Raman spectroscopy is a powerful tool to shine light on solid catalysts. Unfortunately, intense background fluorescence often obscures Raman spectra to the extent that they become uninterpretable. In this work, we use time-gated Raman spectroscopy to improve the spectral quality by the suppression of fluorescence background based on its relatively slow dynamics compared to Raman scattering. The technique is based on an innovative detector design and has been used to study the formation of carbon deposits and subsequent catalyst deactivation during propane dehydrogenation over Pt-Sn-based catalysts. Furthermore, we show the general benefits of time-gating for operando Raman spectroscopy.
- 13:45-14:30
- Zaal 1
The future of plastics. High potential polyesters from biomass and CO2
- Gert-Jan Gruter University of Amsterdam
• Instead of producing renewable versions of molecules that we use today (drop-in) such as bio-based ethylene, propylene and para-xylene (for PET monomer terephthalic acid), we will make use of the structure already present in carbohydrates (and CO2) when developing new monomers. These oxygenates will also be the lower cost products from renewable feedstock. In addition, polycondensates (such as polyesters) are designed for (closed-loop) recycling as these polymers can always be converted back to the monomers (which is not possible for the polyolefins such as PE, PP and PS).
• New materials with unique properties, based on sugar and CO2 feedstock such as FDCA (furan dicarboxylic acid), isosorbide, oxalic acid, glycolic acid and lactic acid will be discussed as examples.
- 15:10-15:35
- Zaal 3
perClass Mira Stage – Lab quality estimation solution based on spectral imaging
- Pavel Paclik Managing director, perClass
Spectral imaging offers non-destructive way to characterize quality of diverse food products. It enables high-throughput estimation of brix, acidity, fruit firmness or moisture content. Compared to point spectroscopy, spectral imaging enables also spatial analysis of heterogeneous products. This allows for novel work-flows such as automated object detection and quality estimation or for characterization of spatial distributions.
In this presentation, we introduce a portable integrated spectral imaging system combining state-of-the-art spectral sensors and data analysis software. We will demonstrate how it is possible to build quality estimation solution in-house without programming or chemometric expertise and how such a solution can be applied along with standard destructive measurements.
