Advanced in vitro intestinal and liver models : technology and biology meet to make drug development more efficient
Drug development is a costly and slow process with an extremely low efficiency. At TNO we try to increase this efficiency by using advanced in vitro models. We have developed InTESTine and InTESTine Chip where we integrate fresh intestinal biopsies in static and dynamic in vitro systems and study absorption and toxicity of different compounds. We have also developed static and dynamic liver models using stem cell based technologies. In this presentation, I will elaborate more on these technologies and show how they help the pharma industry to get more insight on the efficacy of their compounds.
About Hossein Eslami Amirabadi
Hossein Eslami Amirabadi is a postdoc at TNO and Utrecht University creating engineering solutions to biological problems. He did his MSc and PhD in the group of Jaap den Toonder at Eindhoven University of Technology. Having a background in Mechanical Engineering, he developed a microfluidic chip to study cancer cell invasion in 3D during his PhD. At TNO, together with a team of cell biologists and engineers, he has developed InTESTine Chip where they maintain fresh intestinal tissue inside a microfluidic chip to study intestinal absorption and cytotoxicity in the presence of microbiome.