Design of synthetic glycoconjugate vaccines
The advent of multi-antibiotic resistant bacteria together with the lack of new antibiotics lead to the need of exploring new ways to fight infections. A suitable alternative strategy is the production of new glycoconjugate vaccines, which grant a long–lasting protection against a specific bacterial strain. In particular synthetic or semisynthetic glyconjugate vaccines have the advantage of delivering consistent batches and the opportunity to apply chemical modifications that can improve the properties of the conjugates such as the chemical stability and immunogenicity.
About Jacopo Enotarpi
Jacopo Enotarpi is a PhD candidate at Leiden University and part of the European training network Horizon 2020 Marie Skłodowska-Curie-program Glycovax. He has extensive knowledge of different kinds organic chemistry, ranging from carbohydrates and phosphoramidites to glycosylations and solid phase synthesis.
An article starring Jacopo Enotarpi about his research projects has appeared in C2W magazine. Read all about it here.